Uterine fibroids - a frequent pathology in gynecology, which has a number of reasons. Among them, the importance of endocrine disruption is betrayed, developing as a result of changes in the functioning of the hypothalamic - pituitary - ovaries - uterus.
Due to the failure of the neuroendocrine regulation of the ratio of gonadotropic and sex hormones can dramatically change. Thus the development of long-term increase in estrogen levels, and rhythm disturbances of secretion, causing hyperplastic processes in the myometrium, thereby contributing to the development of tumors.
There is local production of estrogen by synthesizing them in a myomatous node, it can support the further development of the tumor independently of ovarian hormones, ensuring the autonomy of growth.
Recently, we consider the theory according to which in the pathogenesis of uterine fibroids, along with estrogen is involved progesterone, reinforcing the mitotic activity of cells in the myometrium during the luteal phase. We must consider the fact that the number of uterine progesterone receptor content in excess of their normal myometrium (in contrast to the estrogen receptor, which number in the same tumor and normal tissue has no significant difference). This feature makes the uterine receptor concentration on the properties close to the endometrium than the myometrium, it is the cause of greater potency myomatous growth than intact muscle of the uterus, at the same level of hormones in the blood.
Violation of the cause of hormonal
of uterine fibroids
A definite place in the development of uterine fibroids is a pathological change in neuromuscular regulation of tumor sites that are totally denervated formations. This is confirmed by the fact that myomas can not be found cholinergic and adrenergic neural structures.
Growth hormone somatotropin is able to initiate the development of uterine fibroids. This assumption is based on the fact that women suffering from acromegaly, this pathology is more frequent than in the general population.
Currently, uterine fibroids treated not only as a hormone-dependent tumors, but also as a consequence of the pathological process of regeneration of the myometrium, damaged as a result of inflammatory changes, intrauterine intervention, traumatic birth. At the same time from the moment of impact of a possible causal factor to identify the tumor may take more than one year.
Development of these tumors may contribute to changes in immunological reactivity, especially against the backdrop of foci of chronic infection.
Today, the causes of uterine fibroids did not accurately studied, many of them are controversial. That information, which is at this stage, you can select a rational approach to prevention and treatment of this disease.
