Preparations of drug therapy for the treatment of uterine fibroids
When the diameter of myoma nodules up to 2 cm, the value of the uterus, not exceeding the size of dvenadtsatinedelnoy pregnancy, mild clinical symptoms, absence of dysfunction of the neighboring organs, intramural or subserous tumor, rapid growth of tumors and contraindications for drugs used is shown holding a conservative medical treatment of uterine fibroids. This tactic is effective before the onset of menopause. Is to appoint the basal (hormone), and symptomatic therapy. It is characterized by complexity and directionality in different parts of the pathological process in the light of all the violations.
The aim of drug therapy
At the core of medical treatment of uterine fibroids is the concept of hormone-dependent nature of the disease. It is based the use of means contributing to reduction of the tumor, further hindering its growth and prevent the development of any secondary changes.
Preparations for medical treatment
Today it is considered a promising use of antiprogestagenov (antagonists of gonadotropin-releasing hormone). The mechanism of action is their classic competitive blockade of endogenous gonadotropin receptors on the membrane of gonadotropic pituitary cells.
The main drugs that are used as conservative treatment of this pathology are antigonadotropiny and synthetic agonists of gonadotropin-releasing hormone, which are by far the most effective drugs in the treatment of uterine fibroids. Antigonadotropiny have antiprogesteronovoe and antiestrogenic action, provoking the development of amenorrhea. Agonist of gonadotropin-releasing hormone causes pharmacological menopause due to pronounced inhibition of gonadotropin secretion.
Medical treatment for uterine myoma
The choice and amount of symptomatic therapy depends on clinical disease and is defined by a strictly individual basis. Pain stopped by taking antispasmodics, NSAIDs, or non-narcotic analgesics. In the presence of uterine bleeding leading to anemia, showing the appointment Haemostatic, iron and tools to help reduce cancer. As a strengthening therapy may be administered adaptogens. For correction of the psycho-emotional disorders using sedatiki to improve microcirculation in the myometrium - antiplatelet agents and anticoagulants in small doses, to normalize the metabolism - antioxidants and multivitamins.
If the size of uterine fibroids that do not exceed 15 mm in patients of reproductive age use combined oral contraceptives with progestin (progesterone analogue, lacking some of the undesirable effects of the latter), or levonorgestrel-containing intrauterine system. These medications help to restore the normal functioning of the hypothalamic-pituitary and ovarian function and improve the state of the myometrium by blocking ovulation.
Perhaps the use of antifibrotic therapy, reason for which is great content in the uterine extracellular matrix composed of collagen, fibronectin, and proteoglycan.
Drug therapy of uterine fibroids may be used alone or part of a combined treatment of uterine fibroids. Selection of drugs at the same time should be solely a gynecologist.
