Syndrome of Morgagni-Stewart-Morel - a disease in which there are obesity, a thickening of the inner plate of the frontal bone and virilization.
Virilization (from the Latin virilis - male) - the appearance of male characteristics in women under the influence of male sex hormone androgen.
The cause of the frontal hyperostosis is unknown. Presumably, the trigger for the disease are changes in the hypothalamic-pituitary system, which occur during the female climacteric.
Microscopic examination of the pituitary in this disorder exhibit many microadenomas (benign tumor of glandular tissue formation), the pituitary gland. In microadenomas is enhanced somatotropic and adrenocorticotropic products pituitary hormones.
Excess of somatostatin causes thickening of the internal plates of the skull bones, enlarged sella turcica (bone box in which the pituitary gland), bony growths of the skull bones and spine. Enhancing production of adrenocorticotropic hormone causes an increased synthesis of adrenal hormones. This is usually manifested Cushing's syndrome light (excess function of the adrenal cortex).
Clinical manifestations of hyperostosis.
There is obesity, high blood pressure, impaired glucose uptake tissues of the human body. Sick women during menopause and beyond. The disease begins gradually. First, there are persistent headaches in the forehead or neck, often compressing character constants not depending on the position of the head. Due to persistent headache appears irritability, nervousness, various sleep disorders.
Gradually develop a uniform whole-body obesity. The bands stretch and there is no, but may appear excessive hair growth on face and body.
Patients worried about shortness of breath, palpitations, high blood pressure. Often under the influence of adrenal hormones is a violation of carbohydrate metabolism and diabetes occurs the second type. The menstrual cycle is disturbed, but the tides, as during menopause does not happen.
Further compounded by disorders of the central nervous system, until the development of depression.
Diagnosis of hyperostosis.
Diagnosis is established on the basis of:
age of patients
characteristic of obesity
excessive growth of body hair.
Pre X-ray examination found thickening of the inner plate of the frontal bone, bone growth in the skull.
The blood found an increased amount of:
somatostatin
adrenocorticotropin
adrenocortical hormones.
Treatment for the syndrome of Morgagni-Stewart-Morel.
Most drug treatment. First of all, is assigned diet with fewer calories and fat carbohydrate-rich foods. Sometimes medications are used to reduce appetite. Necessarily need sufficient exercise. If you have diabetes are appointed agents for its treatment. In the persistent increase in blood pressure are appointed agents for the treatment of hypertension. In some patients there is a need radiation therapy.
