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Monday, 10.08.2020, 18:39
Main » Pediatrics » Pituitary dwarfism 
16:56
Pituitary dwarfism


Pituitary dwarfism

Pituitary dwarfism - is stunted due to lack of somatotropic pituitary. Develops as a consequence of absolute or relative deficiency of growth hormone. When the disease affects the central system functions to regulate growth - is the hypothalamus (defect function neyrotsitov producing releasing hormone) and pituitary gland itself (full otsutstviesomatotropnogo hormone GH). No less important are the gene defect, which controls the secretion of growth hormone, and the defect of the tissue messenger through which the realized effects of growth hormone growth hormone.


Distinguished:
  • pituitary dwarfism (the primary pathology of the pituitary gland)
  • hypothalamic (deficit biosynthesis and secretion of growth hormone-riliztng)
  • Tissue resistance to the action of growth hormone (pathology of growth hormone receptors on the target tissue level).


The most common form of idiopathic growth hormone deficiency. Against the backdrop of a sharp increase in the backlog, delays in growth rate and bone maturation child has a normal body proportions. As a result of underdevelopment of the facial skull bones facial features are small, the bridge sinks, characterized by "doll" face. Hair-thin, high voice. Often there is an excess of body weight. Boys tend to MICROPENIS. Delayed sexual development.

A significant number of growth hormone deficiency with a concomitant deficiency of gonadotropins. Complaints of headaches, blurred vision, vomiting can be suspected intracranial pathology. Stunting in children with growth hormone deficiency progresses with age and the time of diagnosis, usually below - 3 SDS (standard deviation of the coefficient characterizing the degree of deviation from the average child's growth in population for a given chronological age and gender).

The growth rate is a cumulative index that reflects the dynamics of growth over time, and in children with growth hormone deficiency, this figure is significantly reduced and less than 4 cm per year. If pituitary dwarfism requires lifelong replacement therapy with human growth hormone.



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