Treatment of uterine fibroids with combined oral contraceptives
Combined oral contraceptives are used to treat uterine fibroids, when the tumor diameter is less than one and a half inches. For larger sites noted the ambiguity of the effect: the size of the tumors may stabilize or continue to grow. The reason for this is that small fibroids do not become autonomous growth mechanisms are not formed by enzyme systems of local and independent production of connective tissue. In this regard, perhaps, to control the growth of tumors by means of input from outside the progestogens contained in oral contraceptives today. This line of treatment is a priority for women of childbearing age with uterine myoma small size.
The mechanism of action of combined oral contraceptives
The mechanism of action is blockade of the basic pathogenesis of this disease. Appointment of progestogens provides recovery of the hypothalamic-pituitary system, normalizes ovarian function and improve the state of the myometrium.
During the oral contraceptive pill ovulation in the female body is not happening. Not formed corpus luteum, which produces progesterone, which is the strongest and activates mitogen proliferative processes in the uterus. In this case, the level of this hormone is only supported by the faction, produced by adrenal glands, and is very low. The existence of the endometrium without sufficient effect of progesterone is very dangerous.
The structure of modern combined oral contraceptives for the prevention of hyperplastic processes in the mucous membrane of the uterus include progestin, which has many similarities with the progesterone receptor on the characteristics and simultaneously deprived of its adverse effects.
Combined oral contraceptives
in the treatment of uterine fibroids
The type and amount of progestin component are of considerable importance in the integrated effect of these drugs on the risk of development and progression of existing fibroids.
If the woman before taking oral contraceptives in the uterus myoma nodes are missing, then their use will be substantially inhibited by one of the most important mechanisms of disease development (progesterone). Subject to the rules of admission is an important causative factor is excluded, abortion. Use of combined oral contraceptives, a woman does not allow 100% of the cases to avoid the development of uterine fibroids. Since solving the problem of unplanned pregnancy, they do not rule out other factors contributing to the emergence and further growth of the nodes, as infection with sexually transmitted diseases.
Progestins, which are part of these preparations have a stabilizing effect on the growth of the basal nodes after hormone therapy, while improving the effectiveness and efficiency of treatment.
The use of combined oral contraceptives has shown good results in combating such widespread today gynecological pathology as uterine fibroids.